Recently, a research team from Southwest Jiaotong University published a study in Bioactive Materials, introducing mossy-textured hydroxyapatite-modified poly(lactic-co-glycolic acid) microspheres (CaHA/PLGA), a technological breakthrough in the field of medical aesthetic soft tissue augmentation. Composed of 20%-22% CaHA and 78%-80% PLGA, the composite microspheres are fabricated via emulsion and hydrothermal methods, featuring uniform structure, mossy surface, and controllable size with a particle diameter range of 30-60μm.
    Experiments show that in a simulated in vivo environment, the microspheres retain 69.4% of their mass after 12 weeks, demonstrating significantly better degradation stability than pure PLGA microspheres. Its core advantage lies in activating multi-cellular responses including macrophages and adipose-derived mesenchymal stem cells through calcium/TGF-β and chemokine signaling pathways, efficiently promoting collagen regeneration and extracellular matrix assembly, thus providing a long-term solution for facial soft tissue augmentation. The advent of this technology marks a new stage in the composite application of polyester-based microspheres and CaHA microspheres.

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