Recently, significant progress has been made in coating and material interface science, with a systematic analysis of the mechanisms and applications of silane coupling agents and phosphate ester adhesion promoters, providing a scientific approach to improving adhesion on glass, metal and other substrates. Upgrading adhesion from physical interlocking to chemical bonding is key to enhancing coating durability. Featuring dual-functional structures, silane coupling agents form stable covalent bonds via hydrolysis and condensation on glass and silicate substrates, with KH-570 being the top choice for UV-curable systems. Phosphate esters specialize in metallic substrates through strong coordination bonds; double-bond-containing phosphates match UV curing efficiently and greatly boost adhesion on cold-rolled steel, stainless steel and other metals. Studies show that combining the two creates a synergistic 1+1>2 effect. Optimized with a hybrid formula, UV coatings on stainless steel reach 5B initial adhesion, retain 4B after boiling water resistance tests, and show improved MEK rub resistance. These findings offer practical formulations and selection guidance for high-performance coatings in 3C, automotive, anti-corrosion and other industries, driving coatings from easy-peeling to highly durable performance.