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The role of allyl glycidyl ether in pharmaceutical synthesis

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1 As a structural modification monomer

The epoxy and allyl groups of AGE can participate in different chemical reactions respectively, playing a key role in the process of modifying the molecular structure of drugs. For example:
Introduction of epoxy structure: epoxy can react with functional groups such as amines, hydroxyl or carboxyl to form a new drug skeleton.
Functionalization of allyl group: the allyl group of AGE can undergo olefin addition, allyl substitution and other reactions in subsequent reactions, thereby improving molecular diversity.

2 As an intermediate in drug synthesis
AGE can be used as a key intermediate in the synthesis of antiviral, anti-tumor and cardiovascular drugs. For example:
Antiviral drug synthesis: AGE can be used in the synthesis of nucleoside analogs or epoxy compounds to enhance antiviral activity.
Targeted therapy drugs: AGE as a functional group introduction agent can help develop new small molecule targeted drugs.

3 As a chiral auxiliary or ligand
AGE can be used as a ligand in asymmetric catalytic reactions to participate in the synthesis of chiral drugs and enhance the optical purity and activity of drugs. For example, in the synthesis of certain antibiotics and anti-inflammatory drugs, AGE derivatives can be used for chirality control to improve synthesis efficiency.


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