In March 2026, 1,3-Dimethyl-2-imidazolidinone (abbreviated as DMI, CAS No. 80-73-9), a high-performance strong polar aprotic solvent, has become a focus in the chemical, pharmaceutical, new energy and other fields with multiple advantages, successfully realizing the compliant replacement of traditional restricted solvents such as DMF, NMP and DMSO. As a non-hazardous chemical, DMI has an LD₅₀ of more than 5000mg/kg and complies with international norms such as ICH Q3C and REACH, solving the problems of environmental restrictions and export barriers from the source. It has outstanding solubility, with much higher solubility for insoluble substances such as steroid hormones and polyimides than traditional solvents, and can dissolve organic and inorganic substances simultaneously. Meanwhile, DMI has a thermal decomposition temperature of over 200℃, resists strong acids and alkalis, produces no by-products in high-temperature reactions, and is suitable for atmospheric pressure and high-temperature processes. On the production side, DMI can increase the yield of synthetic reactions by 5%-20%, reduce purification costs, and adapt to the whole process from laboratory small-scale tests to industrial mass production. At present, DMI has achieved full-scenario coverage in pharmaceutical synthesis, semiconductor microelectronics, new energy batteries, high-end polymer materials and other fields, and can provide industrial-grade, reagent-grade and other multi-specification products, offering a new choice for the upgrading and development of various industries.
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